Estradiol Valerate / Dienogest Suppliers & Bulk Manufacturers

Available Forms: Tablet

Available Strengths: 1mg+2mg / 0.03mg+2mg

Reference Brands: Natazia (USA), Qlaira (EU), Valette(EU)

Category: Women's Health

Dienogest is a synthetic progestin used in hormonal contraceptives to prevent pregnancy. It works by inhibiting ovulation, thickening cervical mucus, and altering the endometrial lining to reduce the likelihood of implantation.

Product Description:

Estradiol valerate / Dienogest is a modern combined hormonal contraceptive designed to provide effective birth control while using an estrogen closer to the body’s natural hormone. Unlike many traditional contraceptives that contain ethinyl estradiol, this formulation uses estradiol valerate, which converts into 17β-estradiol in the body, a naturally occurring estrogen. The combination is typically supplied in a four-phase dosing regimen that gradually adjusts hormone levels throughout the cycle, including an estrogen step-down and progestin step-up approach, followed by a short two-day hormone-free interval.

Dienogest, the progestin component, is derived from 19-nortestosterone and has strong progestational activity on the endometrium. It is also known for its antiandrogenic properties, which may help improve tolerability in some women. Together, estradiol valerate and dienogest work to prevent ovulation, stabilize the uterine lining, and create hormonal conditions that reduce the chance of pregnancy.

This combination has been shown to provide reliable contraception and is also used in the management of heavy menstrual bleeding in women who prefer oral contraception. Clinical data suggest that its metabolic effects and safety profile are generally comparable to those observed with many established contraceptives.