Butoconazole Nitrate 2% Suppliers & Bulk Manufacturers

Available Forms: Vaginal Cream

Available Strengths: 2%

Reference Brands: Gynazole-1 (USA)

Category: Women's Health

Butoconazole is an imidazole antifungal agent that works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. It is used as a topical vaginal cream for the treatment of Candida albicans infections, providing effective relief from itching, burning, and discharge associated with yeast infections.

Product Description:

Butoconazole is an imidazole antifungal. It inhibits the fungal enzyme that converts lanosterol to ergosterol, the sterol that gives the fungal cell membrane its structure; without it the membrane becomes leaky and the cell dies. Applied vaginally it acts locally, with minimal systemic absorption.

It is used for vulvovaginal candidiasis. Its distinguishing feature is the delivery system: the 2% cream is formulated in a sustained-release vaginal bioadhesive emulsion, so a single application adheres to the vaginal mucosa and releases drug over several days. A single-dose treatment is a real advantage over the three- and seven-day courses of other imidazole creams, where women often stop once symptoms ease. Cure rates are comparable to those regimens. Local burning and itching after application are the usual adverse effects. It is not for use in pregnancy without advice, and the cream base can weaken latex condoms and diaphragms for several days.

Sourcing notes. The single-dose adhesive formulation is what makes this product, not the molecule, and it is not interchangeable with a plain butoconazole cream. Registration is mainly in the US; much of the world uses clotrimazole or fluconazole for the same indication, so confirm the destination market registers it.