Darifenacin Hydrobromide 7.5 mg, 15 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 7.5 mg, 15 mg

Reference Brands: Enablex (USA), Emselex(EU/UK)

Category: Women's Health

Darifenacin is an antimuscarinic agent used to treat overactive bladder with symptoms like frequent or urgent urination and urinary incontinence. It works by blocking muscarinic receptors in the bladder, helping to relax bladder muscles and increase urine storage capacity.

Product Description:

Darifenacin is an antimuscarinic that is selective for the M3 receptor subtype. M3 receptors mediate detrusor muscle contraction in the bladder, so blocking them reduces the involuntary contractions that cause urgency. The selectivity matters because M1 and M2 receptors mediate many of the effects that make older antimuscarinics hard to tolerate — M1 in the brain for cognition, M2 in the heart for rate.

It is used for overactive bladder with urgency, frequency and urge incontinence, in men and women. Its argument against oxybutynin and tolterodine is a lower rate of central effects, which matters in older patients where anticholinergic burden is linked to confusion and, in observational studies, to dementia risk. It is a large molecule with limited brain penetration, reinforcing that profile. Dry mouth and constipation remain the commonest adverse effects, since M3 receptors also serve salivary glands and gut. It is contraindicated in urinary retention, gastric retention and uncontrolled narrow-angle glaucoma, and it is a CYP2D6 and CYP3A4 substrate.

Sourcing notes. Off patent, with generics available. It is an extended-release tablet, so the release mechanism carries its own bioequivalence requirements. Beta-3 agonists now compete directly in this indication.