Doxylamine Succinate 25mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 25mg

Reference Brands: Unisom (USA), Dorminox (EU/UK)

Category: Women's Health

Doxylamine is a first-generation antihistamine with sedative and anticholinergic properties. It is used over-the-counter for short-term treatment of insomnia and as a component in combination therapy (with pyridoxine) for nausea and vomiting of pregnancy. The salt form typically used is doxylamine succinate (or hydrogen succinate) and the dosage forms vary by indication and country. Because of its sedative effect, caution is required with other central nervous system depressants.

Product Description:

Doxylamine is a first-generation antihistamine that blocks histamine H1 receptors and, because it crosses into the brain readily, causes marked sedation. It also has anticholinergic activity. At 25 mg it is used as a sleep aid, available without prescription in several markets, taken shortly before bed for occasional difficulty falling asleep.

Its other role is quite different and is worth distinguishing: combined with pyridoxine (vitamin B6), doxylamine is the best-evidenced treatment for nausea and vomiting of pregnancy, with decades of safety data and a delayed-release formulation designed for morning symptoms. That is a separate product from the plain 25 mg tablet. As a sedating antihistamine, tolerance to the hypnotic effect develops within days, and next-morning drowsiness is common. Anticholinergic effects — dry mouth, blurred vision, constipation, urinary retention — are marked in older patients, where the drug appears on lists of medicines to avoid because of falls and confusion.

Sourcing notes. The plain tablet is usually an over-the-counter product, which changes the buyer to retail rather than pharmacy wholesale. The pregnancy combination is a prescription product with its own registration and evidence base; enquiries should be matched to the right one.