Dydrogesterone 10mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 10mg

Reference Brands: Dirogest (EU), Duphaston (EU)

Category: Women's Health

Dydrogesterone is a synthetic progestogen used to treat conditions associated with progesterone deficiency, such as luteal phase insufficiency, threatened miscarriage, habitual abortion, endometriosis, and premenstrual syndrome. It is also utilized in hormone replacement therapy (HRT) to counteract the effects of unopposed estrogen on the endometrium in individuals with an intact uterus.

Product Description:

Dydrogesterone is a retroprogesterone — its molecular structure is bent in the opposite direction at one carbon compared with natural progesterone. That small change gives it high selectivity for the progesterone receptor with essentially no androgenic, oestrogenic or glucocorticoid activity, and good oral bioavailability, which natural progesterone lacks.

It is used for a range of conditions caused by progesterone deficiency: irregular and heavy periods, secondary amenorrhoea, premenstrual syndrome, endometriosis, threatened and recurrent miscarriage, and as the progestogen component of hormone replacement therapy to protect the endometrium from unopposed oestrogen. In fertility practice it is used for luteal phase support, where oral dosing is a practical advantage over vaginal progesterone. Because it does not suppress ovulation at usual doses, it is not a contraceptive. It is generally well tolerated; headache, nausea and breast tenderness are the common complaints, and breakthrough bleeding can occur.

Sourcing notes. Registered across Europe, Asia, Latin America and the Middle East, but withdrawn from the US market decades ago, so it is not a US product. Off patent with generic supply, particularly from India. Demand is strong in fertility and obstetric practice in Asia.