Dienogest 2mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 2mg

Reference Brands: Visanne (EU)

Category: Women's Health

Dienogest 2 mg tablets are a progestin taken daily to treat endometriosis pain. It shrinks endometrial lesions and is used long term. Reference brands include Visanne; generic versions are available in Europe and Asia. PharmaTradz sources it for importers, hospitals and tenders, and shares GMP certificates and CoA before you commit.

Product Description:

Dienogest is a fourth-generation progestin, structurally a hybrid: it has the 19-nortestosterone backbone that gives strong progestogenic effect on the endometrium, but a cyanomethyl group that removes androgenic activity and adds mild anti-androgenic action. At 2 mg daily it suppresses ovulation only partially, but it creates a stable low-oestrogen environment locally that makes endometriotic lesions atrophy.

It is used for endometriosis, continuously and long term. Its advantage over GnRH analogues is that it does not produce a deep hypo-oestrogenic state, so bone loss and menopausal symptoms are far less of a problem and treatment can continue for years rather than six months. Trials show pain relief comparable to GnRH agonists. The main adverse effect is bleeding pattern disturbance — irregular spotting early on, often settling to amenorrhoea — which patients must be warned about or they stop. Mood changes, headache and breast discomfort occur. It is not a contraceptive at this dose in all markets, so contraception advice is needed.

Sourcing notes. Registered widely in Europe and Asia, though not as a single agent in the US. Off patent in several markets, with generics available. Confirm which indication the destination market registers.