Pralatrexate 20 mg/mL Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 20 mg/mL

Reference Brands: Folotyn (USA)

Category: Oncology Cancer Care

Pralatrexate is a Oncology Cancer Care product available as Injection in strengths 20 mg/mL. It corresponds to the reference brand Folotyn (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Pralatrexate is an antineoplastic agent marketed under the brand name Folotyn and is used in the treatment of relapsed or refractory peripheral T-cell lymphoma (PTCL). It belongs to the class of folate analog metabolic inhibitors and is specifically designed to target rapidly dividing malignant cells. Pralatrexate selectively enters cancer cells through the reduced folate carrier, which is often overexpressed in lymphoma cells, allowing enhanced intracellular accumulation of the drug.

Once inside the cell, pralatrexate inhibits dihydrofolate reductase, an essential enzyme involved in folate metabolism and DNA synthesis. This inhibition disrupts the production of nucleotides required for cell replication, ultimately leading to cell cycle arrest and apoptosis of cancer cells. Due to its targeted mechanism, pralatrexate offers a therapeutic option for patients whose disease has progressed despite prior systemic treatments.

Pralatrexate is administered intravenously and is typically used under specialist oncology supervision. To reduce treatment-related toxicity, supplementation with folic acid and vitamin B12 is recommended before and during therapy. Folotyn represents an important treatment option for patients with limited alternatives in the management of aggressive and difficult-to-treat peripheral T-cell lymphoma.