Lomustine 10 mg, 40 mg, 100 mg Suppliers & Bulk Manufacturers

Available Forms: Capsules

Available Strengths: 10 mg, 40 mg, 100 mg

Reference Brands: Gleostine (USA)

Category: Oncology Cancer Care

Lomustine (CCNU) capsules 10 mg, 40 mg and 100 mg, an oral nitrosourea alkylating agent for brain tumours and Hodgkin lymphoma. For oncology pharmacies, hospital buyers and licensed importers.

Product Description:

Lomustine, also known as CCNU, is a nitrosourea alkylating agent. It cross-links DNA and carbamoylates proteins, which stops cancer cells copying their DNA. Being highly lipid soluble, it crosses the blood-brain barrier, which is why it is valued in brain tumours. It is taken by mouth as capsules of 10 mg, 40 mg and 100 mg, combined to reach a dose based on body surface area. The oral form lets the single dose be taken at home, without an infusion visit.

Lomustine is used for primary and metastatic brain tumours after surgery or radiotherapy, including combination regimens for gliomas, and as a later-line option in Hodgkin lymphoma. It is one single dose, usually no more often than every six weeks, because blood counts fall late and recover slowly. Patients taking it daily by mistake have died, so labels warn to dispense only enough capsules for one dose. Blood counts are checked weekly after each dose. Lung toxicity and secondary cancers are known risks.

Sourcing notes. Lomustine is a cytotoxic, prescription-only medicine. Capsules should not be opened, and staff handling them wear gloves and follow cytotoxic waste rules. Registration needs a CTD dossier, and registered presentations are limited in many markets, so some hospitals obtain it by named-patient import under the importer's permit. Ask for stability data supporting the label storage condition, especially for hot, humid markets. Request a batch CoA, a GMP certificate and a CoPP. Packaging should allow one-dose dispensing, with local-language warnings. Give strengths, capsules per pack, quantity and destination.