Lomustine 10 mg, 40 mg, 100 mg Suppliers & Bulk Manufacturers

Available Forms: Capsules

Available Strengths: 10 mg, 40 mg, 100 mg

Reference Brands: Gleostine (USA)

Category: Oncology Cancer Care

Lomustine is a Oncology Cancer Care product available as Capsules in strengths 10 mg, 40 mg, 100 mg. It corresponds to the reference brand Gleostine (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Lomustine is a nitrosourea alkylating agent with potent antineoplastic activity, widely used in chemotherapy protocols for the treatment of various malignancies. It works by alkylating and crosslinking DNA, which leads to inhibition of DNA and RNA synthesis and ultimately results in cancer cell death. In addition, lomustine carbamoylates DNA and cellular proteins, further disrupting RNA processing and impairing tumor cell replication.

Lomustine is a highly lipophilic compound, allowing it to effectively cross the blood–brain barrier. This unique pharmacokinetic property makes it particularly valuable in the treatment of primary and metastatic brain tumors, where many anticancer agents have limited penetration. It is most commonly used in the management of brain tumors and is also employed as a second-line treatment option for Hodgkin lymphoma, especially in cases where standard therapies have failed.

Internationally known by the abbreviation CCNU, lomustine was originally marketed under the brand name CeeNU and is currently available as Gleostine in regulated markets. Due to its strong cytotoxic activity, lomustine is administered under strict medical supervision as part of carefully monitored chemotherapy regimens.