Idarubicin Hydrochloride 5 mg/5 mL Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 5 mg/5 mL

Reference Brands: Idamycin (USA)

Category: Oncology Cancer Care

Idarubicin Hydrochloride is a Oncology Cancer Care product available as Injection in strengths 5 mg/5 mL. It corresponds to the reference brand Idamycin (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Idarubicin hydrochloride is an anthracycline antileukemic agent widely used in combination chemotherapy regimens for the treatment of acute myeloid leukemia (AML) in adult patients. It is commonly administered alongside other anticancer drugs during induction therapy under strict oncologist supervision. In addition to its approved use in AML, idarubicin hydrochloride is also being studied for its potential role in the treatment of other malignancies.

Pharmacologically, idarubicin hydrochloride works by intercalating into DNA and inhibiting the activity of topoisomerase II, an essential enzyme involved in DNA replication, transcription, and repair. By blocking this enzyme, the drug prevents proper DNA unwinding and cell division, ultimately leading to cancer cell death. The compound is a structural analog of daunorubicin; however, the absence of a methoxy group increases its lipophilicity, allowing for enhanced cellular uptake and greater antitumor activity.

Like other anthracyclines, idarubicin hydrochloride also affects chromatin structure by inducing histone eviction, further disrupting cancer cell survival mechanisms. Due to its potent cytotoxic effects, its use requires careful dosing and monitoring in specialized oncology settings.