Romidepsin 10 mg Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 10 mg

Reference Brands: Istodax (USA/EU)

Category: Oncology Cancer Care

Romidepsin is a Oncology Cancer Care product available as Injection in strengths 10 mg. It corresponds to the reference brand Istodax (USA/EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Romidepsin is an anticancer agent used in the treatment of cutaneous T-cell lymphoma (CTCL) and certain types of peripheral T-cell lymphoma (PTCL) in adult patients who have received prior systemic therapy. It is marketed under the brand name Istodax and is administered intravenously under specialist oncology supervision. Romidepsin belongs to a class of compounds known as depsipeptides and is derived from a natural product originally isolated from the bacterium Chromobacterium violaceum.

Pharmacologically, romidepsin functions as a histone deacetylase (HDAC) inhibitor. Following intracellular activation, it binds to HDAC enzymes and blocks their activity, leading to changes in gene expression within malignant cells. These epigenetic modifications result in cell cycle arrest, cellular differentiation, and programmed cell death (apoptosis). In addition to its direct antitumor effects, romidepsin has been shown to inhibit hypoxia-induced angiogenesis and reduce levels of several heat shock protein 90 (Hsp90)-dependent oncoproteins, further contributing to its antineoplastic activity.

Due to its potent mechanism of action and safety considerations, romidepsin therapy requires careful patient selection, monitoring, and administration in controlled clinical settings.