Floxuridine 500 mg Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 500 mg

Reference Brands: -

Category: Oncology Cancer Care

Floxuridine 500 mg powder for injection, a fluoropyrimidine given by hepatic arterial infusion for gastrointestinal cancer spread to the liver. For specialist hospitals, oncology pharmacies and importers.

Product Description:

Floxuridine (FUDR) is a fluoropyrimidine antimetabolite, the deoxyribose form of fluorouracil. In the body it becomes fluorodeoxyuridine monophosphate, which blocks thymidylate synthase and halts DNA synthesis. It comes as a sterile freeze-dried powder, 500 mg per vial, reconstituted with sterile water. What sets it apart is the route: continuous infusion into the hepatic artery. The liver removes much of it on first pass, so tumour in the liver meets a high concentration while systemic exposure stays modest.

The approved use is palliative treatment of gastrointestinal adenocarcinoma that has spread to the liver, in patients who are not candidates for surgery. It is delivered through an implanted or external arterial infusion pump placed by a surgeon or interventional radiologist, so it belongs in specialist hepatobiliary and oncology centres. Hepatic arterial use can cause chemical hepatitis and sclerosing cholangitis, and liver tests guide dose interruptions. Gastritis, duodenal ulcer, diarrhoea and mouth sores are common. The label advises hospital admission for the first course.

Sourcing notes. Only a few finished-product sources exist and registration is concentrated in a limited set of markets, so buyers usually order for a defined patient group and plan ahead. Unopened vials are stored at room temperature; the reconstituted solution has a limited refrigerated shelf life set by the label. Confirm compatibility with your infusion pump before buying. Ask for a CoA per batch covering assay, sterility and endotoxin, plus GMP certificate and CoPP. It is a cytotoxic, prescription-only medicine. State vial count and pump system.