Tafenoquine bulk supplier for pharma manufacturers

Tafenoquine 100mg, 150mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 100mg, 150mg

Reference Brands: Arakoda (USA), Krintafel(USA)

Tafenoquine is an antimalarial drug used for the treatment and prevention of Plasmodium vivax malaria. It belongs to the 8-aminoquinoline class and works by eliminating dormant liver stages of the parasite to prevent relapse. Tafenoquine is available as oral tablets and marketed under brand names Krintafel (treatment) and Arakoda (prophylaxis). It is placed under Critical Care for specialty infectious disease management.

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Product Description:

Tafenoquine is an 8-aminoquinoline antimalarial, related to primaquine but with a much longer half-life of around two weeks. That single property is what makes it significant: it kills the dormant liver forms of Plasmodium vivax that cause relapses months after the original infection, and it does so in a single dose where primaquine requires fourteen days of treatment that patients frequently do not complete.

It is used for radical cure of P. vivax malaria, given with a blood-stage drug such as chloroquine, and at a different dose for prophylaxis in travellers, taken weekly. The constraint on its use is glucose-6-phosphate dehydrogenase deficiency: in people with the enzyme deficiency, 8-aminoquinolines cause acute haemolysis, and because tafenoquine cannot be stopped once taken, quantitative G6PD testing is required before every course — not the qualitative test that sufficed for primaquine. It is contraindicated in pregnancy and breastfeeding where the infant's status is unknown.

Sourcing notes. Quantitative G6PD testing capability is a prerequisite, and its absence is the main barrier to adoption in endemic countries. The treatment and prophylaxis products are separate registrations with different strengths and brands. This product belongs under antimalarial, not antiviral.

Tafenoquine — third party manufacturing & bulk supply

Tafenoquine 100mg, 150mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Tafenoquine is supplied as Tablets — an oral solid dosage form, so the indicative MOQ is 200,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Tafenoquine listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Tafenoquine is used for the radical cure and prevention of malaria caused by Plasmodium vivax. It helps eliminate dormant liver-stage parasites (hypnozoites) to prevent relapse and is also used for malaria prophylaxis in travelers. It offers a long-acting alternative to traditional regimens like primaquine.

Tafenoquine is a synthetic 8-aminoquinoline antimalarial compound. It works by generating oxidative stress within the parasite, disrupting essential cellular processes and eliminating both blood-stage and liver-stage forms of the malaria parasite.

Tafenoquine is marketed under the trade names Krintafel for radical cure of P. vivax and Arakoda for malaria prophylaxis.

Krintafel and Arakoda are manufactured by GlaxoSmithKline (GSK) in partnership with the Medicines for Malaria Venture (MMV). Arakoda for prophylaxis is also distributed by 60 Degrees Pharmaceuticals.

The generic name of the product is tafenoquine.

Common brand names include Krintafel and Arakoda.

Tafenoquine (Krintafel and Arakoda) is manufactured in GSK’s approved global facilities and distributed through licensed pharmaceutical partners. Production for prophylaxis formulations may also involve 60 Degrees Pharmaceuticals under regulatory authorization.