Artemether + Lumefantrine Tablet 20 mg/120 mg per tablet Suppliers & Bulk Manufacturers

Available Forms: Tablet

Available Strengths: 20 mg/120 mg per tablet

Reference Brands: Coartem(EU)

Category: Antimalarial Drugs

Artemether 20 mg with lumefantrine 120 mg tablets, a WHO-recommended ACT for uncomplicated falciparum malaria. For national malaria programmes, tender buyers, NGOs, importers and hospital pharmacies.

Product Description:

Artemether with lumefantrine is an artemisinin-based combination therapy, or ACT, for malaria. Artemether, an artemisinin derivative, kills blood-stage parasites very quickly. Lumefantrine acts more slowly and stays in the body for days, clearing the parasites that remain. Pairing a fast drug with a long-acting partner protects each from resistance. This page covers the standard tablet of 20 mg artemether and 120 mg lumefantrine; one strength serves all ages, with tablets per dose set by body weight.

It is a WHO-recommended first-line treatment for uncomplicated Plasmodium falciparum malaria and is on the WHO Model List of Essential Medicines. The course is six doses over three days: the second dose eight hours after the first, then twice daily. Each dose should be taken with fatty food or milk, because lumefantrine is poorly absorbed on an empty stomach. It is not for severe malaria, which needs parenteral therapy. Take care with QT prolongation and other QT-prolonging drugs. A dispersible tablet exists separately for young children.

Sourcing notes. For donor-funded and UN tenders, WHO prequalification or approval by a stringent regulatory authority is normally required, so ask for that evidence first. Request a CTD dossier with bioequivalence data and zone IVb stability, since most demand is in hot, humid regions. Blister packs are usually printed by weight band with pictorial instructions, which helps where literacy is low. Ask for a CoA for every batch, the GMP certificate and a CoPP. List the weight-band packs, quantities, label language and minimum shelf life on arrival.