Pentobarbital Sodium Suppliers & Bulk Manufacturers

Available Forms: Tablets / Oral solution / Injection

Available Strengths: 50 mg, 100 mg , 15 mg/mL, 25 mg/mL, 50 mg/mL, 65 mg/mL

Reference Brands: Nembutal (USA)

Category: Critical Care

Pentobarbital Sodium is a Critical Care product available as Tablets / Oral solution / Injection in strengths 50 mg, 100 mg , 15 mg/mL, 25 mg/mL, 50 mg/mL, 65 mg/mL. It corresponds to the reference brand Nembutal (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Pentobarbital sodium, known as pentobarbital in the US and pentobarbitone in the UK and Australia, is a short-acting barbiturate with sedative, hypnotic, and anticonvulsant properties. It is used in clinical practice as a preanesthetic agent, for short-term management of insomnia, and to control convulsions in emergency situations. Pentobarbital acts on the central nervous system by enhancing the inhibitory effects of gamma-aminobutyric acid (GABA), leading to decreased neuronal excitability, sedation, and hypnosis.

Historically, Pentobarbital was marketed under the brand name Nembutal, though its production in capsule form was discontinued by Abbott Pharmaceuticals in 1999, largely replaced by benzodiazepines. Despite this, pentobarbital remains important in specialized medical applications. It is employed to reduce intracranial pressure in Reye syndrome, manage traumatic brain injuries, and induce medically controlled coma in patients with severe cerebral ischemia or acute liver failure refractory to other treatments.

Pentobarbital sodium is administered via oral tablets, oral solution, or intravenous injection, depending on the therapeutic indication. Its rapid onset and short duration of action make it a valuable agent in critical care settings, anesthesia, and emergency management, offering precise control over sedation, seizure activity, and neuroprotection in acute medical scenarios.