Protamine Sulfate 10 mg/mL, 50 mg/mL Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 10 mg/mL, 50 mg/mL

Reference Brands: Generic formulations marketed under different names

Category: Critical Care

Protamine Sulfate is a Critical Care product available as Injection in strengths 10 mg/mL, 50 mg/mL. It corresponds to the reference brand Generic formulations marketed under different names. Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Protamine sulfate is a specialized medication used to reverse and neutralize the anticoagulant effects of heparin. It acts as a specific antagonist to heparin-induced anticoagulation by forming a stable complex with heparin, effectively restoring normal blood clotting. Protamine sulfate is a highly basic, polycationic, low-molecular-weight protein, originally derived from salmon sperm, and is also available in recombinant forms for pharmaceutical use. Its unique mechanism makes it an essential agent in critical care and surgical settings where rapid heparin reversal is required.

Clinically, protamine sulfate is used in cases of heparin or low molecular weight heparin overdose, during cardiovascular surgeries such as cardiopulmonary bypass, and in obstetric procedures when heparin anticoagulation must be neutralized. It is administered intravenously, with the dosage and infusion rate carefully calculated based on the amount of heparin to be reversed and the patient’s clinical condition.

While highly effective, protamine sulfate must be used cautiously due to potential adverse effects such as hypotension, bradycardia, and rare severe allergic reactions. With careful monitoring, protamine sulfate provides rapid and reliable reversal of anticoagulation, making it a critical tool for healthcare teams managing patients in surgery, critical care, and emergency settings.