Pralidoxime 1 g/10 mL Suppliers & Bulk Manufacturers
Available Forms: Injection
Available Strengths: 1 g/10 mL
Reference Brands: Protopam Chloride (USA)
Category: Critical Care
Pralidoxime is a Critical Care product available as Injection in strengths 1 g/10 mL. It corresponds to the reference brand Protopam Chloride (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.
Product Description:
Pralidoxime, also known as 2-PAM (2-pyridine aldoxime methyl chloride), is a critical antidote used in the management and treatment of organophosphate poisoning. Belonging to the oxime class of drugs, pralidoxime works by reactivating acetylcholinesterase that has been inactivated by organophosphate compounds, thereby restoring normal nerve function and alleviating the toxic effects of cholinergic overstimulation. It is commonly administered in combination with atropine and, when needed, benzodiazepines such as diazepam or midazolam to manage seizures or severe symptoms.
Pralidoxime is available as chloride or iodide salts and is supplied as a sterile injectable solution for intravenous or intramuscular use. It is particularly valuable in cases of poisoning with organophosphate-based pesticides or nerve agents, where rapid intervention is essential to prevent life-threatening complications. Clinical use requires careful dosing based on the severity of exposure and patient condition, with monitoring of vital signs and cholinesterase activity to guide therapy.
Due to its effectiveness and rapid action, pralidoxime is an essential component of emergency and critical care protocols for organophosphate toxicity. It has a well-characterized safety profile, though adverse effects such as hypertension, tachycardia, and mild neuromuscular symptoms may occur if administered too rapidly. Its targeted mechanism and role in multidisciplinary care make it indispensable in managing acute organophosphate poisoning.
Pralidoxime — third party manufacturing & bulk supply
Pralidoxime 1 g/10 mL is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:
What to include when you enquire
- Destination market — determines which manufacturers hold the right site-level approvals
- First order quantity and estimated annual volume
- Whether you need a registration dossier or the product is already registered
- Packaging, labelling and language requirements
- Incoterms and required shelf life
Indicative minimum order quantity
Pralidoxime is supplied as Injection — an injectable dosage form, so the indicative MOQ is 50,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.
Manufacturers of Pralidoxime listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding. Narcotic drugs and controlled substances are supplied strictly against valid import and export permits issued by the competent authorities.
Request a quote for Pralidoxime →The Trade Mark owner has been correctly identified under the heading Manufacturer / TM Owner as required by the Act.
Frequently Asked Questions
Pralidoxime is used to treat organophosphate poisoning by reactivating acetylcholinesterase and reversing the toxic effects caused by these compounds.
Pralidoxime is a synthetic quaternary ammonium compound formulated as a sterile solution for intravenous or intramuscular injection.
Pralidoxime is marketed under trade names such as Protopam Chloride in the USA and various generic versions in the UK and EU.
Pralidoxime is manufactured by multiple pharmaceutical companies worldwide as a generic and branded injectable solution.
The generic name is pralidoxime chloride.
Protopam Chloride (USA), generics in UK/EU.
Pralidoxime is manufactured in the USA, EU, and other countries by licensed pharmaceutical companies producing sterile injectable medications.
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