Aminocaproic Acid 500mg, 250 mg/mL Suppliers & Bulk Manufacturers

Available Forms: Tablet/ Oral Solution/ Injection

Available Strengths: 500mg, 250 mg/mL

Reference Brands: Amicar (USA)

Category: Critical Care

Aminocaproic acid is an antifibrinolytic agent that helps prevent or reduce excessive bleeding by inhibiting the breakdown of blood clots. It is used in conditions such as surgery, trauma, or bleeding disorders to stabilize clots and control hemorrhage. The drug is available in oral tablets, oral solution, and injectable forms, and is typically used under medical supervision in critical care or surgical settings.

Product Description:

Aminocaproic acid is an antifibrinolytic. It occupies the lysine binding sites on plasminogen, the sites that let plasminogen and plasmin attach to fibrin. Blocked in that way, plasmin cannot break down a clot that has already formed, so bleeding from excessive fibrinolysis is reduced. It is the same mechanism as tranexamic acid, which is roughly ten times more potent and has largely displaced it.

It is used where fibrinolysis is causing or worsening bleeding: after cardiac surgery, in bleeding from the urinary tract, in some haematological disorders, and to control mucosal bleeding in haemophilia and after dental work in patients with bleeding disorders. The oral solution is used for mouth and throat bleeding. Because it stabilises clots everywhere, the main concern is thrombosis, and it is contraindicated in active intravascular clotting and in bleeding above the ureters from a kidney source, where clot in the ureter can obstruct it. Dose is reduced in renal impairment.

Sourcing notes. Off patent. Tablets, oral solution and injection are separate registrations, and the injection is the hospital product. Supply has narrowed as tranexamic acid took over, and availability rather than price is often the issue in markets where only one form is registered.