Rolapitant Hydrochlorid 90 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 90 mg

Reference Brands: Varubi(USA/LATAM), Varuby(EU)

Category: Critical Care

Rolapitant Hydrochlorid is a Critical Care product available as Tablets in strengths 90 mg. It corresponds to the reference brands Varubi(USA/LATAM), Varuby(EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Rolapitant hydrochloride is an orally administered, selective neurokinin-1 (NK1) receptor antagonist with potent antiemetic activity, primarily used to prevent chemotherapy-induced nausea and vomiting (CINV) in adult patients receiving moderately or highly emetogenic cancer therapy. The drug works by competitively binding to NK1 receptors in the central nervous system, thereby blocking the activity of substance P, a key neuropeptide responsible for triggering nausea and vomiting. By inhibiting this pathway, rolapitant helps prevent both acute and delayed emesis associated with cancer chemotherapy.

Rolapitant distinguishes itself from other NK1 receptor antagonists through its rapid onset of action and extended half-life, allowing for effective, long-lasting protection against CINV with a single oral dose. It is typically administered in combination with other antiemetic agents, such as 5-HT3 receptor antagonists and corticosteroids, to maximize patient comfort and adherence to cancer treatment regimens.

As a centrally acting antiemetic, rolapitant provides an important supportive care option for oncology patients, improving quality of life during chemotherapy by reducing the burden of nausea and vomiting and allowing patients to better tolerate their prescribed cancer therapy.