Mecamylamine Hydrochloride 2.5 mg, 5 mg,10 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 2.5 mg, 5 mg,10 mg

Reference Brands: Vecamyl (USA/EU)

Category: Neurology

Mecamylamine Hydrochloride is a Neurology product available as Tablets in strengths 2.5 mg, 5 mg,10 mg. It corresponds to the reference brand Vecamyl (USA/EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Mecamylamine, marketed under brand names such as Inversine and Vecamyl, is a non-selective, non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs). Originally introduced in the 1950s as an orally active antihypertensive agent, it functions as a ganglionic blocker, modulating autonomic nervous system activity to lower blood pressure. Over time, its use for hypertension has declined, and it is now more commonly employed as a research tool and in specialized clinical applications.

Mecamylamine is also used as an anti-addictive agent to support smoking cessation, acting on α3β4 nicotinic receptors in the brain to reduce nicotine dependence. Additionally, it has demonstrated potential in neurological conditions such as Tourette syndrome, providing relief from tics when conventional therapies have failed. Experimental studies have explored its role in psychiatric disorders, including major depressive disorder, where (S)-mecamylamine (TC-5214) was investigated as an augmentation therapy. While Phase III clinical trials did not achieve primary efficacy endpoints, the research highlighted the potential of nicotinic receptor antagonists in neuropsychiatric modulation.

Available in oral tablet form, mecamylamine hydrochloride offers a versatile pharmacological profile, combining ganglionic blockade with central nervous system effects. Its unique mechanism continues to make it valuable in clinical research and targeted therapeutic applications.