Cyclobenzaprine Hydrochloride 5mg, 7.5mg, 10mg, 30mg Suppliers & Bulk Manufacturers

Available Forms: Tablets, Capsules

Available Strengths: 5mg, 7.5mg, 10mg, 30mg

Reference Brands: Flexeril(USA/EU), Amrix (USA), Fexmid (USA)

Category: Neurology

Cyclobenzaprine hydrochloride is a centrally acting skeletal muscle relaxant used to relieve muscle spasms and pain associated with acute musculoskeletal conditions. It works by reducing tonic somatic motor activity at the brainstem level, leading to muscle relaxation without directly affecting muscle function.

Product Description:

Cyclobenzaprine is a centrally acting skeletal muscle relaxant that is structurally almost identical to amitriptyline — it differs by a single double bond. It acts mainly at the brainstem, reducing tonic somatic motor activity through effects on serotonergic and noradrenergic descending pathways, rather than acting on the muscle itself. It is used for short-term relief of muscle spasm in acute, painful musculoskeletal conditions, usually for two to three weeks.

The tricyclic structure shapes the adverse effect profile: drowsiness in a large share of patients, dry mouth and other anticholinergic effects, and the class cautions around arrhythmia, heart block and recent myocardial infarction. It must not be combined with MAO inhibitors, and serotonin syndrome has been reported with SSRIs, SNRIs and tramadol. It is not effective for spasticity from cerebral or spinal cord disease.

Sourcing notes. Generic immediate-release tablets are commodity supply, largely for the Americas; registration elsewhere is patchy. The 15 mg and 30 mg strengths are extended-release capsules, a different formulation needing its own dissolution specification and bioequivalence data, so they should not be quoted as simple line extensions of the 5 mg and 10 mg tablets. Cyclobenzaprine is not a controlled substance, which simplifies trade compared with carisoprodol, a common alternative in some markets.