Opicapone Suppliers & Bulk Manufacturers

Available Forms: Capsules

Available Strengths: 25 mg, 50 mg

Reference Brands: Ongentys (USA/EU)

Category: Neurology

Product Description:

Opicapone, marketed under the brand name Ongentys, is a peripherally acting catechol-O-methyltransferase (COMT) inhibitor used as adjunctive therapy with levodopa in patients with Parkinson’s disease. It is specifically indicated for individuals experiencing “off” episodes, where the effects of levodopa wear off before the next dose, leading to a return of motor symptoms.

Opicapone works by inhibiting the COMT enzyme in the peripheral tissues, which is responsible for the breakdown of levodopa in the body. By blocking this enzyme outside the brain, opicapone enhances and prolongs the availability of levodopa, allowing more of it to reach the central nervous system where it is converted into dopamine. Importantly, opicapone does not inhibit COMT within the brain, contributing to its targeted peripheral action.

As a result of sustained levodopa levels, dopamine concentrations in brain regions responsible for movement and coordination are better maintained. This leads to improved control of Parkinson’s disease symptoms such as stiffness, slowness of movement, and reduced mobility. With its once-daily dosing and long-lasting COMT inhibition, opicapone provides a convenient and effective option for optimizing levodopa therapy in Parkinson’s disease management.