Terlipressin Injection Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 0.85 mg/5 mL

Reference Brands: Terlivaz (USA)

Category: Critical Care

Terlipressin is indicated in the treatment of bleeding oesophageal varices. The administration of terlipressin serves the emergency care for acute bleeding oesophageal varices until endoscopic therapy is available.

Product Description:

Terlipressin is a synthetic analogue of vasopressin and acts as a potent vasoactive agent used primarily in critical care and hospital settings. It works as a vasopressin receptor agonist, producing vasoconstriction that helps increase systemic vascular resistance and improve blood pressure. Terlipressin is especially valuable in patients where conventional vasopressors, such as norepinephrine, have shown limited effectiveness.

Clinically, terlipressin is approved for improving kidney function in adults with hepatorenal syndrome associated with rapid deterioration of renal function in patients with advanced liver disease. By selectively constricting splanchnic blood vessels, it improves renal perfusion and supports kidney recovery. Terlipressin is also widely used in the management of acute bleeding from esophageal varices, where it helps reduce portal hypertension and control hemorrhage.

Although terlipressin has been studied for use in norepinephrine-resistant septic shock, recent international guidelines advise against its routine use for septic shock in adults. Due to its strong vasoconstrictive properties, terlipressin should be administered intravenously under strict medical supervision, with careful monitoring to minimize potential cardiovascular and ischemic complications.