Ropinirole Hydrochloride Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg, 5 mg

Reference Brands: Requip (USA)

Category: Neurology

Ropinirole hydrochloride immediate-release tablets, 0.25 mg to 5 mg, a dopamine agonist for Parkinson's disease and restless legs syndrome. For importers, distributors, hospitals and neurology tender buyers.

Product Description:

Ropinirole hydrochloride is a non-ergot dopamine agonist. It stimulates D2 and D3 receptors in the brain, standing in for the dopamine lost in Parkinson's disease. This page covers immediate-release film-coated tablets of 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg and 5 mg. The long ladder of strengths exists because therapy starts very low and climbs slowly over weeks. Prolonged-release ropinirole is a separate product and is not swapped dose for dose with this form.

Ropinirole is approved for Parkinson's disease, alone early on or added to levodopa, and for moderate to severe primary restless legs syndrome. In Parkinson's the tablet is usually taken three times a day with food to ease nausea. In restless legs it is taken once, one to three hours before bedtime, at far smaller doses. Labels warn of sudden sleep onset, which matters for driving, and impulse control disorders such as compulsive gambling. It is metabolised by CYP1A2, so ciprofloxacin and fluvoxamine raise levels. Doses are tapered, not stopped abruptly.

Sourcing notes. Ropinirole is prescription-only. Ask for a CTD or ACTD dossier with bioequivalence data against the reference product and zone IVb stability for hot, humid markets. Tablets come in PVC/PVDC or alu-alu blisters, or HDPE bottles, stored at room temperature away from moisture. Documents to collect are a CoA for every batch, the GMP certificate and a CoPP. In your enquiry, list the exact strengths, any titration packs, pack size, label language and shelf life on arrival.