Available Forms: Tablets
Available Strengths: 50 mg ,100 mg
Reference Brands: Xadago (USA/EU)
Category: Neurology
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Product Description:
Safinamide is a medication used in the management of idiopathic Parkinson’s disease in adults who experience motor fluctuations, commonly known as “off” episodes. It is marketed under the brand name Xadago and is prescribed as an add-on therapy for patients receiving a stable dose of levodopa, either alone or in combination with other Parkinson’s disease treatments. Safinamide is particularly beneficial for patients whose symptoms re-emerge when the effects of levodopa wear off.
Safinamide has a unique and multi-modal mechanism of action. It acts as a selective and reversible inhibitor of monoamine oxidase B (MAO-B), an enzyme responsible for the breakdown of dopamine in the brain. By inhibiting MAO-B, safinamide helps increase and prolong dopamine activity, improving motor control. In addition, safinamide modulates abnormal glutamate release, which contributes to both motor and non-motor symptom control.
Safinamide is used as an add-on treatment to levodopa, alone or in combination with other Parkinson’s disease medications, to manage motor fluctuations in adults with Parkinson’s disease.
Safinamide is a synthetic small-molecule compound developed to selectively inhibit MAO-B and modulate abnormal glutamate release in the brain.
The trade name of safinamide is Xadago.
Safinamide (Xadago) is marketed by Newron Pharmaceuticals, with commercialization partnerships in various regions.
The generic name is safinamide mesylate.
The brand name is Xadago.
Safinamide is manufactured by authorized pharmaceutical manufacturing partners supplying the USA, EU, and UK markets under regulatory approval.
Strength: 125 mg/mL, 200 mg, 250 mg, 300 mg, 500 mg, 100 mg/mL
Form: Tablet / Capsule/ Injection / Oral syrup
Reference Brands: Depakene (USA), Depakine (EU/LATAM), Valprol (India)
Strength: 50 mg, 100 mg
Form: Tablets
Reference Brands: Ubrelvy (USA/India)
Strength: 100 mg
Reference Brands: Tasmar (USA/EU)
Strength: 0.25 mg, 0.5 mg, 1 mg, 2 mg, 3 mg, 4 mg, 5 mg
Reference Brands: Requip (USA)
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