Tolcapone Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 100 mg

Reference Brands: Tasmar (USA/EU)

Category: Neurology

Tolcapone is available in Tablets and strengths such as 100 mg. Sourced from GMP-certified and ISO-compliant manufacturers, this API meets global pharmacopeia standards (USP/EP/JP as applicable). Ideal for pharmaceutical formulation and commercial manufacturing, Tolcapone is supplied in bulk quantities with complete regulatory support including DMF, COA, and MSDS.

Tolcapone can be exported to over 30 countries across Asia, Africa, Europe, and Latin America. Flexible packaging, competitive pricing, and a verified supplier network make Pharmatradz a trusted sourcing partner for pharmaceutical companies and contract manufacturers worldwide.

Product Description:

Tolcapone is a prescription medicine used in the management of Parkinson’s disease and is commonly marketed under the brand name Tasmar. It belongs to a class of drugs known as catechol-O-methyltransferase (COMT) inhibitors. Tolcapone works by blocking the COMT enzyme, which is responsible for breaking down levodopa in the body. By inhibiting this enzyme, tolcapone increases and prolongs the effect of levodopa, helping to improve motor symptoms such as stiffness, tremor, and slowness of movement in patients receiving levodopa/carbidopa therapy. It is considered a selective, potent, and reversible nitrocatechol-type COMT inhibitor.

Due to its mechanism and strong effect, tolcapone is typically used as an add-on treatment when standard Parkinson’s therapy does not provide sufficient symptom control. However, its clinical use is limited because it has been associated with serious liver toxicity. For this reason, strict liver function monitoring is required during treatment, and marketing authorization has been suspended or restricted in several countries. As a result, tolcapone is generally reserved for carefully selected patients under close medical supervision.