Naphazoline bulk supplier for pharma manufacturers

Naphazoline 0.05%, 0.1% Suppliers & Bulk Manufacturers

Q: What is Naphazoline made from?

Naphazoline is the active chemical agent with formula CââHââNâ (for the free base) and most commonly presented as its hydrochloride or nitrate salt (e.g., naphazoline hydrochloride).

Available Forms: Nasal drops/spray

Available Strengths: 0.05%, 0.1%

Reference Brands: Privine (USA),

Category: Allergy Medication

Naphazoline is a topical nasal and ocular decongestant belonging to the imidazoline class. It acts as an α-adrenergic agonist, causing vasoconstriction of mucosal blood vessels and providing rapid relief from nasal congestion and eye redness associated with allergic rhinitis, conjunctivitis, sinusitis, and common cold.

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Product Description:

Naphazoline is an imidazoline-derived sympathomimetic acting as an alpha-adrenergic agonist. Applied topically to nasal or conjunctival mucosa it produces vasoconstriction, relieving congestion and redness within minutes. Onset is rapid and the effect is unambiguous, which accounts for its enduring consumer popularity.

The constraint that defines this product. Sustained topical use produces rebound congestion — rhinitis medicamentosa — in which withdrawal provokes congestion worse than the original symptom, driving a cycle of continued use. Labelling in most markets therefore limits use to three consecutive days, and patient non-compliance with that limit is the principal safety issue associated with the class. Ophthalmic naphazoline carries a parallel caution regarding rebound hyperaemia, and is contraindicated in narrow-angle glaucoma.

Paediatric exposure warrants particular care: accidental ingestion by young children can produce marked central nervous system depression, and several regulators have acted on packaging and concentration for this reason.

Sourcing notes. Naphazoline is inexpensive and widely available, so the commercial questions are presentation and regulatory classification rather than supply. Nasal drops, metered nasal spray and ophthalmic drops are distinct manufacturing propositions with different plant approvals — ophthalmic in particular requires sterile eye-preparation scope. Over-the-counter status, permitted concentration and pack size all vary by market and should be confirmed against the destination regulator before artwork is finalised.

Naphazoline — third party manufacturing & bulk supply

Naphazoline 0.05%, 0.1% is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Naphazoline is supplied as Nasal drops/spray — a dosage form priced by order value, so the indicative MOQ is a minimum order value of USD 5,000 per product. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Naphazoline listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Naphazoline is a rapid-acting sympathomimetic vasoconstrictor used topically to relieve redness of the eye (from minor irritation) and to reduce nasal congestion (via nasal mucosal vasoconstriction).

Naphazoline is the active chemical agent with formula C₁₄H₁₄N₂ (for the free base) and most commonly presented as its hydrochloride or nitrate salt (e.g., naphazoline hydrochloride).

Some major trade names include Naphcon®, Naphcon-A®, AK-Con®, Albalon®, Clear Eyes®, Vasocon®.

Various companies market Naphazoline formulations depending on region and form. For example, the “Albalon” brand is/was marketed by Allergan and “AK-Con” by Akorn in the U.S.

The generic name is

Brand names include Naphcon®, Naphcon-A®, AK-Con®, Albalon®, Clear Eyes® (and other combinations/variants).

Manufacturing varies by product, country, and license holder. As an API, naphazoline hydrochloride is supplied by firms such as C2 PHARMA Limited (Ireland) which cites global supply for ophthalmic API.