Mitotane 500 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 500 mg

Reference Brands: Lysodren (USA)

Category: Oncology Cancer Care

Mitotane is a Oncology Cancer Care product available as Tablets in strengths 500 mg. It corresponds to the reference brand Lysodren (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Mitotane, marketed under the brand name Lysodren, is a steroidogenesis inhibitor and cytostatic antineoplastic agent used primarily in the treatment of adrenocortical carcinoma (ACC) and, in some cases, Cushing's syndrome. It is a synthetic derivative of the insecticide DDT and an isomer of p,p'-DDD, also known as 2,4'-(dichlorodiphenyl)-2,2-dichloroethane (o,p'-DDD). Mitotane selectively destroys adrenal cortex cells and inhibits steroid synthesis, reducing tumor growth and hormone overproduction associated with ACC.

Lysodren is indicated for patients with persistent or metastatic adrenocortical carcinoma, those who are not candidates for surgery, or patients at high risk of recurrence following surgical resection. Clinical studies have shown that adjuvant therapy with Mitotane after radical surgery significantly prolongs the recurrence-free interval compared to surgery alone. The medication is available in oral tablet form, with a carefully titrated dosing regimen to balance efficacy and tolerability. Mitotane’s dual role in controlling tumor proliferation and abnormal steroid production makes it a cornerstone in the management of ACC and certain endocrine disorders. As an orphan drug, Lysodren addresses the needs of a rare patient population with advanced adrenal tumors.