Trifluridine/Tipiracil Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 15 mg/6.14 mg , 20 mg / 8.19 mg

Reference Brands: Lonsurf (USA)

Category: Oncology Cancer Care

Trifluridine/Tipiracil is a Oncology Cancer Care product available as Tablets in strengths 15 mg/6.14 mg , 20 mg / 8.19 mg. It corresponds to the reference brand Lonsurf (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Lonsurf, a combination of trifluridine and tipiracil, is a fixed-dose oral medication used as a third- or fourth-line treatment for metastatic colorectal cancer and metastatic gastric or gastroesophageal junction adenocarcinoma in patients who have previously undergone chemotherapy and targeted therapies. Trifluridine, a nucleoside analog, incorporates into tumor DNA, disrupting DNA synthesis and inhibiting cancer cell proliferation. Tipiracil, a thymidine phosphorylase inhibitor, prevents the rapid breakdown of trifluridine, enhancing its bioavailability and therapeutic effectiveness.

By combining these two agents, Lonsurf provides a targeted approach to slow tumor growth in patients with advanced cancer who have limited treatment options. It is administered orally in tablet form and is dosed according to body surface area and treatment cycles. Lonsurf’s mechanism ensures that trifluridine remains active long enough to exert cytotoxic effects on tumor cells while minimizing systemic exposure and toxicity. Approved in multiple regulated markets including the USA, EU, and UK, Lonsurf has become a vital therapy for patients with metastatic colorectal and gastric cancers, offering an important option when standard chemotherapy and biologic therapies have been exhausted.