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Isoniazid + Rifampicin bulk supplier for pharma manufacturers

Isoniazid + Rifampicin Suppliers & Bulk Manufacturers

Available Forms: Capsules / Tablet

Available Strengths: 300mg+150mg, 100mg+150mg

Reference Brands: Rifamate (USA), IsonaRif (USA), Rifinah(UK)

Category: Antibiotics

Isoniazid + Rifampicin is a fixed-dose antitubercular antibiotic combination used for the treatment and prevention of tuberculosis (TB). It works by inhibiting bacterial cell wall synthesis (isoniazid) and blocking RNA transcription (rifampicin), providing a synergistic effect and reducing the risk of drug resistance. Isoniazid + Rifampicin is available in Capsules / Tablet and strengths such as 300mg+150mg, 100mg+150mg. Sourced from GMP-certified and ISO-compliant manufacturers, this API meets global pharmacopeia standards (USP/EP/JP as applicable). Ideal for pharmaceutical formulation and commercial manufacturing, Isoniazid + Rifampicin is supplied in bulk quantities with complete regulatory support including DMF, COA, and MSDS.

Technical Specifications & Supply Details
Lead Time 7 to 60 days (depending on batch size & schedule)
MOQ As per manufacturer’s batch size
COA Available with every batch
Regulatory Dossier / DMF Available upon request
Export Documentation FSC, COA, Manufacturing License, Product Permission
Standards IP, BP, USP
Certifications WHO-GMP, EU-GMP, USFDA (as applicable)

Isoniazid + Rifampicin can be exported to over 30 countries across Asia, Africa, Europe, and Latin America. Flexible packaging, competitive pricing, and a verified supplier network make Pharmatradz a trusted sourcing partner for pharmaceutical companies and contract manufacturers worldwide.

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📘 Sourcing Guide

Product Description:

Isoniazid + Rifampicin, also referred to as Isoniazid + Rifampin, is a fixed-dose combination medication used for the treatment of tuberculosis (TB). This combination contains two potent first-line antitubercular agents: Isoniazid, which inhibits mycolic acid synthesis in the mycobacterial cell wall, and Rifampicin, which blocks bacterial RNA transcription. Together, they provide synergistic bactericidal activity, making the combination highly effective against Mycobacterium tuberculosis.

The medication is designed for oral administration and is commonly used alongside other antituberculosis drugs as part of a multidrug regimen to enhance efficacy and prevent drug resistance. Available in both tablet and syrup formulations, Isoniazid + Rifampicin allows for flexible dosing in adults and pediatric patients. Its fixed-dose combination simplifies therapy, ensures adherence, and supports consistent therapeutic outcomes. With a well-established safety profile and proven effectiveness, Isoniazid + Rifampicin remains a cornerstone in global TB management strategies.

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Frequently Asked Questions

Isoniazid + Rifampicin combination is used for the treatment of active Mycobacterium tuberculosis (TB) infection. It is a first-line therapy for tuberculosis and is also used in certain latent TB cases as part of combination therapy. The combination provides synergistic bactericidal activity against TB bacteria and helps prevent drug resistance.

The combination contains two active ingredients: isonicotinic acid hydrazide (Isoniazid) and rifampicin (Rifampin). Both act together to inhibit mycobacterial cell wall synthesis and RNA transcription, resulting in effective killing of Mycobacterium tuberculosis. Excipients in tablets or syrups are included to allow stability, accurate dosing, and oral administration.

Common trade names include Rifamate, Isonorif, and Rifinah, though specific brands vary by region and manufacturer.

Manufacturers include Sanofi, Cipla, Macleods, Lupin, and other regional pharmaceutical companies producing fixed-dose combinations for TB treatment.

Isoniazid (isonicotinic acid hydrazide) + Rifampicin (rifampin).

Rifamate, Isonorif, Rifinah, and other regional brand names depending on country regulations.

Global manufacturing includes India, Europe, and the USA. Major manufacturers are Sanofi (Europe), Cipla and Macleods (India), and Lupin (India).

Yes, Isoniazid + Rifampicin is available with DMF and other regulatory documents such as COA and MSDS. These can be provided upon request for qualified buyers.

Absolutely. Sample requests are accepted for formulation trials and quality checks. Please submit an enquiry to initiate the process.

Our manufacturing partners are GMP-certified and comply with ISO and WHO standards, ensuring global quality benchmarks.

Lead times vary based on quantity and destination, but most orders are fulfilled within 1–3 weeks. Express shipping options are available.

Yes, Isoniazid + Rifampicin is exported to over 30 countries across Asia, Africa, Europe, and Latin America. We support documentation for customs and regulatory clearance.

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