Cefepime (4th Gen) Injectable (IV/IM) 1 g, 2 g, 4 g per vial Suppliers & Bulk Manufacturers

Available Forms: Injectable (IV/IM)

Available Strengths: 1 g, 2 g, 4 g per vial

Reference Brands: Maxipime(US & EU)

Category: Antibiotics

Cefepime powder for injection in 1 g, 2 g and 4 g vials, a fourth-generation cephalosporin for serious hospital infections. For hospital pharmacies, importers, distributors and antibiotic tender buyers.

Product Description:

Cefepime is a fourth-generation cephalosporin. Like other beta-lactams it binds penicillin-binding proteins and stops bacteria building their cell wall. It enters Gram-negative cells quickly and resists many AmpC beta-lactamases, so it covers Pseudomonas aeruginosa and Enterobacterales as well as methicillin-sensitive staphylococci. ESBL producers usually break it down. This page covers sterile powder in vials listed as 1 g, 2 g and 4 g, reconstituted for intravenous infusion or deep intramuscular injection.

Labelled uses include moderate to severe pneumonia, empirical therapy of febrile neutropenia, complicated urinary tract infections, skin infections and, with metronidazole, complicated intra-abdominal infections. WHO places it in the Watch group of its AWaRe classification, so stewardship rules apply. Infusions usually run over about 30 minutes every 8 to 12 hours. Doses must be cut in renal impairment, because accumulation can cause encephalopathy, myoclonus and non-convulsive seizures. It is avoided after serious beta-lactam allergy, and Clostridioides difficile diarrhoea is a recognised risk.

Sourcing notes. Cephalosporins must be made in dedicated or fully segregated beta-lactam facilities, so ask for a GMP certificate covering sterile cephalosporin production. The 1 g and 2 g vials are the standard strengths; confirm that any 4 g presentation is registered in your market. A CTD or ACTD dossier should cover sterility assurance, endotoxins, particulate matter and stability of dry powder and reconstituted solution. Dry vials are stored at room temperature, protected from light. Ask for a CoA per batch, the CoPP and the vial and stopper specification. State strength, vials per carton and any diluent.