Doxercalciferol Suppliers & Bulk Manufacturers

Available Forms: Capsules / Injection

Available Strengths: 0.5 mcg, 1 mcg, 2.5mcg, 2 mcg/mL

Reference Brands: Hectorol (USA)

Category: Nephrology

Doxercalciferol is a vitamin D analogue that lowers parathyroid hormone in secondary hyperparathyroidism of chronic kidney disease. It comes as 0.5, 1 and 2.5 mcg capsules and a 2 mcg/ml injection given during dialysis. The original brand is Hectorol. We quote from GMP-approved manufacturers and confirm document status, lead time and MOQ for each order.

Product Description:

Doxercalciferol is a synthetic vitamin D2 analogue, 1-alpha-hydroxyvitamin D2. It is a prodrug activated in the liver rather than the kidney, which is the point: in chronic kidney disease the kidney can no longer perform the final activation step for natural vitamin D, so an analogue that bypasses it still works. Once activated it suppresses parathyroid hormone synthesis and secretion.

It is used for secondary hyperparathyroidism in chronic kidney disease, both in dialysis patients and before dialysis. Vitamin D analogues lower PTH effectively but raise calcium and phosphate absorption from the gut, so hypercalcaemia and hyperphosphataemia are the limiting adverse effects, and calcium, phosphate and PTH are monitored, with the dose adjusted or held accordingly. Elevated calcium-phosphate product contributes to vascular calcification, which is why treatment is titrated rather than maximised. It is often used alongside a phosphate binder.

Sourcing notes. Off patent, with generic capsules and injection in the US. The injection is given during dialysis sessions, which makes dialysis chains the main buyers. Registration outside the US is limited — alfacalcidol, calcitriol and paricalcitol are the alternatives in most other markets, so confirm what the destination registers.