Bumetanide Suppliers & Bulk Manufacturers

Available Forms: Tablet / Injection

Available Strengths: 0.5 mg, 1 mg, 2 mg, 0.25 mg/mL

Reference Brands: Bumex (USA), Burinex(EU)

Category: Nephrology

Bumetanide is a potent loop diuretic that works by inhibiting sodium and chloride reabsorption in the loop of Henle, promoting rapid urine output. It is used to manage fluid retention (edema) due to heart failure, liver cirrhosis, or renal impairment, and sometimes for high blood pressure when other diuretics are insufficient. It acts faster and is more potent than furosemide.

Product Description:

Bumetanide is a loop diuretic that blocks the sodium-potassium-chloride cotransporter in the thick ascending limb of the loop of Henle. It is roughly forty times more potent by weight than furosemide, so 1 mg of bumetanide corresponds to about 40 mg of furosemide, and dosing errors between the two are a recognised hazard.

Its practical advantage over furosemide is absorption. Furosemide's oral bioavailability varies widely between patients and falls further when the gut wall is oedematous in heart failure; bumetanide is absorbed almost completely and much more predictably. It is therefore often used when a patient fails to respond to oral furosemide. It is used for oedema in heart failure, kidney disease and cirrhosis. Adverse effects are those of potent diuresis: dehydration, hypokalaemia, hyponatraemia, hypomagnesaemia, raised uric acid and, at high doses, hearing disturbance, though less than with furosemide.

Sourcing notes. Off patent and inexpensive. Tablets and injection are separate registrations. Because of the potency difference, labelling clarity matters: quotations should state the strength unambiguously, and packaging that could be confused with furosemide should be avoided.