Acetazolamide 250 mg, 500 mg, 500 mg/10 mL Suppliers & Bulk Manufacturers

Available Forms: Tablets/ capsules/ Injectable

Available Strengths: 250 mg, 500 mg, 500 mg/10 mL

Reference Brands: Diamox (USA/EU)

Category: Nephrology

Acetazolamide is a carbonic anhydrase inhibitor used to reduce fluid retention and lower intraocular pressure. It is commonly prescribed for glaucoma, altitude sickness, edema, and certain types of seizures. Available as oral tablets, extended-release capsules, and IV injection, it helps manage fluid balance and related symptoms. Use under medical supervision.

Product Description:

Acetazolamide inhibits carbonic anhydrase, the enzyme that converts carbon dioxide and water into bicarbonate and hydrogen ions. In the proximal tubule of the kidney that reaction drives bicarbonate reabsorption, so blocking it causes bicarbonate, sodium and water to be lost in the urine, producing a mild diuresis and a metabolic acidosis. The same enzyme makes aqueous humour in the eye and cerebrospinal fluid in the brain.

That breadth explains its uses: glaucoma, where it lowers intraocular pressure; acute mountain sickness, where the induced acidosis stimulates breathing and speeds acclimatisation; idiopathic intracranial hypertension; some forms of epilepsy; and, in intensive care, metabolic alkalosis in ventilated patients. As a diuretic it is weak and self-limiting, because the acidosis it creates blunts its own effect. It is a sulfonamide, so caution applies in sulfa allergy. Paraesthesia, taste disturbance and fatigue are common, and it can precipitate kidney stones and hypokalaemia.

Sourcing notes. Off patent and inexpensive, and on essential medicines lists. Tablets, sustained-release capsules and injection are separate registrations, and the injection is the hospital and ophthalmic surgery product. Supply has been interrupted in some markets; availability is a more common obstacle than price.