Metolazone bulk supplier for pharma manufacturers

Metolazone 2.5 mg, 5 mg, and 10 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 2.5 mg, 5 mg, and 10 mg

Reference Brands: Zaroxolyn (US), Zytanix (EU), Metoz (EU)

Metolazone is a thiazide-like diuretic used to treat high blood pressure (hypertension) and fluid retention (edema) associated with heart failure, kidney disease, or liver disease. It works by helping the kidneys remove excess water and salt from the body, reducing blood volume and swelling. Metolazone is available as oral tablets in strengths of 2.5 mg, 5 mg, and 10 mg, usually taken once daily or as directed by a physician.

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Product Description:

Metolazone is a quinazoline diuretic, thiazide-like in mechanism: it blocks the sodium-chloride cotransporter in the distal convoluted tubule. What distinguishes it from true thiazides is that it keeps working at low glomerular filtration rates, where hydrochlorothiazide becomes ineffective, and it appears to have some action in the proximal tubule as well.

That makes it the standard partner drug for diuretic resistance. In heart failure and advanced kidney disease, patients on high-dose loop diuretics stop responding because the distal tubule adapts and reabsorbs the sodium the loop diuretic delivered to it. Adding metolazone blocks that escape — sequential nephron blockade — and the resulting diuresis can be dramatic. It is given typically thirty minutes before the loop diuretic dose. The same power is the danger: profound sodium, potassium and magnesium loss, dehydration and acute kidney injury can follow, so it is used for short courses with close monitoring of electrolytes, weight and renal function.

Sourcing notes. Off patent, but the supplier base is narrow and it has been in shortage in several markets. Tablet strengths differ in bioavailability between formulations historically, so matching the registered reference product matters. Demand comes from heart failure and renal units.

Metolazone — third party manufacturing & bulk supply

Metolazone 2.5 mg, 5 mg, and 10 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Metolazone is supplied as Tablets — an oral solid dosage form, so the indicative MOQ is 200,000 units. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Metolazone listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Metolazone is listed as Tablets in 2.5 mg, 5 mg, and 10 mg. Further strengths and pack presentations are confirmed with the manufacturer at RFQ stage.

Metolazone is referenced against Zaroxolyn (US), Zytanix (EU), Metoz (EU). Reference brands are shown for identification only and remain the property of their respective trademark owners.