Cholic Acid 250 mg Suppliers & Bulk Manufacturers
Available Forms: Capsules
Available Strengths: 250 mg
Reference Brands: Cholbam (USA), Orphacol (EU)
Category: Gastrointestinal Drugs
Cholic Acid is a Gastrointestinal Drugs product available as Capsules in strengths 250 mg. It corresponds to the reference brands Cholbam (USA), Orphacol (EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.
Product Description:
Cholic acid, also known chemically as 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid, is a primary bile acid naturally synthesized in the liver from cholesterol. It is a white crystalline substance that is insoluble in water but soluble in alcohol and acetic acid. Salts of cholic acid are called cholates. Along with chenodeoxycholic acid, cholic acid is one of the two major bile acids in humans, existing in roughly equal concentrations. It plays a central role in bile acid metabolism, facilitating the digestion and absorption of dietary fats and fat-soluble vitamins.
Cholic acid derivatives are formed from cholyl-CoA, which conjugates with glycine or taurine to produce glycocholic and taurocholic acids, respectively. Functionally, cholic acid regulates bile acid synthesis by downregulating cholesterol-7-α-hydroxylase, the rate-limiting enzyme in bile acid production. This regulation is essential for maintaining cholesterol and bile acid homeostasis in the body. While cholic acid is crucial for normal liver and digestive function, other bile acids, such as chenodeoxycholic acid, are used therapeutically for specific conditions like gallstones due to their ability to modify bile composition.
Cholic Acid — third party manufacturing & bulk supply
Cholic Acid 250 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:
What to include when you enquire
- Destination market — determines which manufacturers hold the right site-level approvals
- First order quantity and estimated annual volume
- Whether you need a registration dossier or the product is already registered
- Packaging, labelling and language requirements
- Incoterms and required shelf life
Manufacturers of Cholic Acid listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding. Narcotic drugs and controlled substances are supplied strictly against valid import and export permits issued by the competent authorities.
Request a quote for Cholic Acid →The Trade Mark owner has been correctly identified under the heading Manufacturer / TM Owner as required by the Act.
Frequently Asked Questions
Cholic acid is used to treat bile acid synthesis disorders, including certain inherited and congenital liver conditions. It helps supplement deficient bile acids, improve bile flow, support fat digestion and absorption, and reduce the accumulation of toxic intermediates in the liver.
Cholic acid is a naturally occurring bile acid, synthesized chemically for therapeutic use. It is formulated as oral capsules for supplementation in patients with bile acid metabolism deficiencies.
Cholic acid is marketed under trade names such as Cholbam in the USA and Orphacol in the EU and UK.
Cholic acid is manufactured by pharmaceutical companies including Retrophin, Inc. (Cholbam) and Recordati Rare Diseases (Orphacol), along with generic manufacturers in various regions.
The generic name is cholic acid.
The brand names are Cholbam and Orphacol.
Cholic acid is manufactured in GMP-approved pharmaceutical facilities, with production and distribution in the USA, EU, and UK according to regional regulatory approvals.
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