Trientine Tetrahydrochloride 150 mg, 250 mg Suppliers & Bulk Manufacturers
Available Forms: Tablets, Capsules
Available Strengths: 150 mg, 250 mg
Reference Brands: Syprine (USA), Cuprior (EU/UK)
Category: Gastrointestinal Drugs
Trientine Tetrahydrochloride is a Gastrointestinal Drugs product available as Tablets, Capsules in strengths 150 mg, 250 mg. It corresponds to the reference brands Syprine (USA), Cuprior (EU/UK). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.
Product Description:
Trientine tetrahydrochloride is a chelating agent used in the management of Wilson’s disease, a rare genetic disorder characterized by excessive accumulation of copper in the body. Trientine is the hydrochloride salt of triethylenetetramine (TETA), an organic polyamine compound that binds copper ions and facilitates their elimination through urinary excretion. By reducing free copper levels, trientine helps prevent progressive damage to the liver, brain, and other organs associated with copper toxicity.
Trientine tetrahydrochloride is primarily indicated for patients who are intolerant to D-penicillamine therapy and may also be used as an alternative first-line treatment in certain cases. It does not contain sulfur and is generally associated with a more favorable tolerability profile compared to penicillamine.
The medication is approved for use in adults, adolescents, and pediatric patients aged five years and older. In the European Union and the United Kingdom, trientine tetrahydrochloride is marketed under the brand name Cuprior, while trientine hydrochloride is marketed in the United States under the brand name Syprine. Trientine plays a critical role in long-term copper control and disease stabilization in patients with Wilson’s disease when used under appropriate medical supervision.
Trientine Tetrahydrochloride — third party manufacturing & bulk supply
Trientine Tetrahydrochloride 150 mg, 250 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:
What to include when you enquire
- Destination market — determines which manufacturers hold the right site-level approvals
- First order quantity and estimated annual volume
- Whether you need a registration dossier or the product is already registered
- Packaging, labelling and language requirements
- Incoterms and required shelf life
Manufacturers of Trientine Tetrahydrochloride listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding. Narcotic drugs and controlled substances are supplied strictly against valid import and export permits issued by the competent authorities.
Request a quote for Trientine Tetrahydrochloride →The Trade Mark owner has been correctly identified under the heading Manufacturer / TM Owner as required by the Act.
Frequently Asked Questions
Trientine tetrahydrochloride is used for the treatment of Wilson’s disease, a rare inherited disorder characterized by excessive accumulation of copper in the liver, brain, and other organs. It is indicated for patients who are intolerant to penicillamine or require alternative copper-chelating therapy.
Trientine tetrahydrochloride is a synthetic polyamine compound that functions as a copper-chelating agent. It binds free copper in the body to form stable complexes that are eliminated mainly through urinary excretion.
Trientine tetrahydrochloride is marketed under the trade name Cuprior in the European Union and the United Kingdom. In the United States, trientine is available as trientine hydrochloride under the brand name Syprine.
Cuprior is marketed by Orphalan in the EU and UK, while Syprine is marketed in the United States by Bausch Health Companies Inc.
The generic name is trientine tetrahydrochloride. In the U.S. market, the salt form used is trientine hydrochloride.
The brand name of trientine tetrahydrochloride is Cuprior in the EU and UK markets.
Trientine tetrahydrochloride is manufactured in GMP-compliant facilities approved by EU and U.S. regulatory authorities, with production depending on the registered brand and target market.
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