Plecanatide 3 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 3 mg

Reference Brands: Trulance (USA)

Category: Gastrointestinal Drugs

Plecanatide is a Gastrointestinal Drugs product available as Tablets in strengths 3 mg. It corresponds to the reference brand Trulance (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Plecanatide is a guanylate cyclase-C agonist approved by the US Food and Drug Administration for the treatment of adults with chronic idiopathic constipation (CIC). Chronic constipation significantly affects quality of life and healthcare utilization, and plecanatide represents a newer therapeutic option within the intestinal secretagogue class. It is a 16-amino-acid synthetic peptide and a structural analog of the human hormone uroguanylin, designed to act locally within the intestinal lumen.

Plecanatide works by activating guanylate cyclase-C receptors on the intestinal epithelium, increasing cyclic GMP levels, which promotes fluid secretion and accelerates intestinal transit. Clinical efficacy and safety were demonstrated in two large randomized, double-blind, placebo-controlled trials in adults with CIC. Treatment with plecanatide at doses of 3 mg and 6 mg resulted in a significantly higher proportion of durable complete spontaneous bowel movement responders compared with placebo. In addition, plecanatide significantly improved associated symptoms such as straining, stool consistency, and bloating.

Patients treated with plecanatide reported high satisfaction levels, improved quality of life, and willingness to continue therapy. The medication was generally well tolerated, with a low incidence of treatment-emergent adverse events, including diarrhea. Plecanatide’s targeted luminal action and favorable safety profile make it an effective option for long-term management of chronic idiopathic constipation.