Resmetirom 80 mg ,100 mg Suppliers & Bulk Manufacturers
Available Forms: Tablets
Available Strengths: 80 mg ,100 mg
Reference Brands: Rezdiffra (USA)
Category: Gastrointestinal Drugs
Resmetirom (Rezdiffra, Madrigal Pharmaceuticals) is a once-daily tablet for MASH (metabolic dysfunction-associated steatohepatitis) with moderate to advanced liver fibrosis but no cirrhosis. The US FDA approved it in March 2024 as the first medicine for this condition. The dose is 80 mg, or 100 mg for people weighing 100 kg or more.
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Product Description:
Resmetirom is a liver-directed, selective thyroid hormone receptor beta agonist. Hepatic THR-beta drives lipid metabolism, so selective agonism reduces intrahepatic fat without the cardiac and bone effects that come from THR-alpha activity. It was the first drug approved specifically for metabolic dysfunction-associated steatohepatitis with moderate to advanced fibrosis, on accelerated approval against histological endpoints.
Dosing is by body weight rather than titration, and the drug interaction profile is the practical constraint: it is a CYP2C8 substrate, and strong CYP2C8 inhibition is contraindicated. Statin co-prescription needs attention because many of these patients are already on one and exposure can rise.
Sourcing notes. Originator, on patent, no generic. Approval status differs markedly between regions and is still moving, so confirm the position in the destination market rather than assuming it follows the US.
Also known as: resmetirom (Spanish, Portuguese, Italian), resmétirom (French), Resmetirom (German), 瑞司美替罗 (Chinese).
How Resmetirom is supplied today, and licensing ahead of patent expiry
Frequently Asked Questions
Resmetirom is used for the treatment of adults with non-cirrhotic metabolic dysfunction–associated steatohepatitis (MASH/NASH) with moderate to advanced liver fibrosis.
Resmetirom is a small-molecule, synthetic thyroid hormone receptor-beta selective agonist designed to target liver tissue.
The trade name of resmetirom is Rezdiffra.
Resmetirom (Rezdiffra) is manufactured and marketed by Madrigal Pharmaceuticals.
The generic name of Resmetirom is resmetirom.
The brand name of Resmetirom is Rezdiffra.
Resmetirom (Rezdiffra) is manufactured for Madrigal Pharmaceuticals, United States, through approved pharmaceutical manufacturing facilities compliant with FDA regulations.
Rezdiffra (Resmetirom) is developed and sold by Madrigal Pharmaceuticals. PharmaTradz handles enquiries for authorised supply of the originator product, named-patient import where it is not registered, and licensing or development work ahead of patent expiry.
El resmetirom es un agonista del receptor beta de la hormona tiroidea que actúa en el hígado y está indicado, junto con dieta y ejercicio, en adultos con esteatohepatitis asociada a disfunción metabólica (MASH, antes NASH) sin cirrosis y con fibrosis hepática moderada a avanzada. Se utiliza con receta y bajo la supervisión de un especialista. PharmaTradz ayuda a importadores, distribuidores y hospitales con licencia a localizar resmetirom de fabricantes certificados según las normas GMP.
O resmetirom é um agonista do receptor beta do hormônio tireoidiano com ação no fígado, indicado, junto com dieta e exercícios, para adultos com esteato-hepatite associada à disfunção metabólica (MASH, antes chamada NASH) sem cirrose e com fibrose hepática moderada a avançada. É usado com prescrição e sob supervisão de um especialista. A PharmaTradz ajuda importadores, distribuidores e hospitais licenciados a encontrar resmetirom de fabricantes certificados em GMP.
Le resmétirom est un agoniste du récepteur bêta des hormones thyroïdiennes à action hépatique, indiqué, en association avec un régime alimentaire et de l'exercice physique, chez l'adulte atteint de stéatohépatite associée à un dysfonctionnement métabolique (MASH, anciennement NASH) non cirrhotique avec une fibrose hépatique modérée à avancée. Il est prescrit sur ordonnance et utilisé sous la surveillance d'un spécialiste. PharmaTradz aide les importateurs, distributeurs et hôpitaux agréés à trouver du resmétirom auprès de fabricants certifiés BPF (GMP).
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