Butenafine Hydrochloride 1% Suppliers & Bulk Manufacturers

Available Forms: Creams

Available Strengths: 1%

Reference Brands: Lotrimin Ultra (USA), Mentax (USA/EU)

Category: Derma Drugs

Butenafine is a benzylamine antifungal structurally related to allylamines like terbinafine. It inhibits squalene epoxidase, an enzyme essential for fungal cell membrane synthesis, leading to cell death. It is primarily used topically to treat common skin fungal infections and provides relief from itching, burning, and scaling.Butenafine is a benzylamine antifungal structurally related to allylamines like terbinafine. It inhibits squalene epoxidase, an enzyme essential for fungal cell membrane synthesis, leading to cell death. It is primarily used topically to treat common skin fungal infections and provides relief from itching, burning, and scaling.

Product Description:

Butenafine is a benzylamine antifungal, structurally related to the allylamines such as terbinafine and working the same way: it inhibits squalene epoxidase, an early enzyme in fungal ergosterol synthesis. Blocking it starves the fungal membrane of ergosterol and causes toxic squalene to accumulate inside the cell, which is fungicidal against dermatophytes rather than merely fungistatic — the practical difference from azole creams, which mostly stop growth rather than killing.

It is used for tinea pedis, tinea cruris, tinea corporis and pityriasis versicolor. Being fungicidal and highly lipophilic, it persists in the stratum corneum after treatment stops, which allows short courses — often one week for athlete's foot between the toes, against the four weeks typical of azole creams. That adherence advantage is its main selling point. Local burning, stinging and itching are the usual adverse effects, and contact dermatitis occurs occasionally.

Sourcing notes. Off patent, and over the counter in several markets, which changes the buyer from pharmacy wholesaler to retail chain. Cream is the main presentation. Registration is concentrated in the US, Japan and parts of Asia; in Europe terbinafine cream dominates the same niche, so confirm what the destination market registers.