Clindamycin / Tretinoin Gel Suppliers & Bulk Manufacturers

Available Forms: Gel

Available Strengths: 1.0% + 0.025% w/w, 1.0% + 0.05% w/w

Reference Brands: Ziana (USA/LATAM), Veltin (USA), Clindate-T (India)

Category: Derma Drugs

Clindamycin+Tretinoin is a combination of two medicines, used to treat acne, which appears as spots or pimples on your face, chest, or back. This medicine works by attacking the germs that cause them and rejuvenates sun-damaged skin.

Product Description:

Clindamycin phosphate 1.2% / tretinoin 0.025% gel is a topical combination therapy indicated for the treatment of acne vulgaris in patients aged 12 years and older. This once-daily formulation combines clindamycin, a lincosamide antibiotic that reduces acne-causing bacteria, with tretinoin, a retinoid that promotes skin cell turnover and prevents clogged pores. Together, they provide a dual mechanism of action that addresses both the microbial and follicular components of acne.

The efficacy and safety of this combination gel are well-established through extensive clinical studies. Three pivotal 12-week, randomized, vehicle-controlled trials involving over 1,800 subjects demonstrated significant improvement in inflammatory and non-inflammatory acne lesions. Additionally, an open-label 52-week study with 442 participants confirmed its long-term tolerability and skin safety. Pooled analyses from a total of 4,550 subjects further support the consistency of therapeutic outcomes.

Results from the Phase 3 studies in 845 subjects with mild to severe facial acne showed that the gel achieved clear or almost clear skin in a substantial proportion of patients, with many experiencing at least a 2-grade improvement in acne severity scores. Clindamycin phosphate 1.2% / tretinoin 0.025% gel is therefore a proven, effective, and safe once-daily option for managing acne vulgaris.