Sarecycline Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 60 mg, 100 mg, 150 mg

Reference Brands: Seysara (USA)

Category: Derma Drugs

Product Description:

Sarecycline is a narrow-spectrum, tetracycline-derived antibiotic specifically developed for the treatment of moderate to severe acne vulgaris. Marketed under the brand name Seysara, it was approved by the U.S. FDA in October 2018 for the treatment of inflammatory, non-nodular acne lesions in patients 9 years of age and older. Its approval was supported by two large, randomized, well-controlled clinical trials that evaluated both facial and truncal acne, including lesions on the back and chest, in more than 2,000 patients.

Sarecycline has a unique chemical structure characterized by a long C7 moiety, which allows it to directly interact with bacterial messenger RNA (mRNA). This structural feature contributes to its targeted antibacterial activity. Unlike traditional tetracyclines, Sarecycline exhibits a limited spectrum of action, primarily against Gram-positive bacteria that are clinically relevant in acne, particularly Cutibacterium acnes.

Due to its minimal activity against Gram-negative bacteria commonly found in the gastrointestinal tract, Sarecycline is associated with a lower risk of disrupting normal gut microflora. This targeted profile makes it well suited for long-term acne management, offering effective lesion reduction with improved tolerability compared to broader-spectrum antibiotics.