Telmisartan & Chlorthalidone Tablet 40mg + 6.25mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 40mg + 6.25mg

Reference Brands:

Category: Heart Disorder

Telmisartan+Chlorthalidone contains two medicines, both of which help to control high blood pressure. Lowering blood pressure helps to reduce your risk of having a heart attack or a stroke in the future.

Product Description:

This tablet combines telmisartan, an angiotensin II receptor blocker, with chlorthalidone, a thiazide-like diuretic. Telmisartan blocks the AT1 receptor and has the longest half-life of its class, giving true 24-hour control. Chlorthalidone increases sodium and water excretion and lowers peripheral resistance over time; it is longer-acting and, in outcome trials, more effective at preventing cardiovascular events than hydrochlorothiazide, the diuretic usually paired with an ARB.

The combination is used when one agent does not control blood pressure. Blocking the renin-angiotensin system alongside a diuretic is complementary: the diuretic activates that system, and telmisartan blocks the response. Telmisartan also reduces the potassium loss chlorthalidone causes. Chlorthalidone can still cause hypokalaemia, hyponatraemia, raised uric acid and raised glucose, so electrolytes are checked, particularly in older patients. The combination is contraindicated in pregnancy, and renal function and potassium are monitored after starting.

Sourcing notes. Widely registered in India and increasingly elsewhere, though the telmisartan-hydrochlorothiazide pairing remains the standard combination in most regulated markets. The fixed-dose product needs its own bioequivalence data. Low-dose chlorthalidone content requires good content uniformity.