Colesevelam hydrochloride bulk supplier for pharma manufacturers

Colesevelam Hydrochloride 625 mg, 3.75 g Suppliers & Bulk Manufacturers

Available Forms: Tablets / Oral suspension

Available Strengths: 625 mg, 3.75 g

Reference Brands: Welchol(USA), Cholestagel (EU/UK)

Colesevelam is a bile acid sequestrant that binds bile acids in the intestine, preventing their reabsorption. This helps lower LDL cholesterol and modestly improves blood sugar control in patients with type 2 diabetes. It’s often used alongside statins or other lipid-lowering therapies.

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Product Description:

Colesevelam is a bile acid sequestrant: a non-absorbed polymer that binds bile acids in the intestine so they are excreted rather than recycled. The liver then converts more cholesterol into bile acids, which increases LDL receptor activity and lowers LDL cholesterol. It binds bile acids more specifically and with higher capacity than the older resins, so the dose is smaller and tolerance better.

It is used to lower LDL cholesterol, alone or with a statin, and in familial hypercholesterolaemia in children. It also modestly lowers HbA1c in type 2 diabetes, an effect approved in some markets, though the mechanism is not fully understood. Constipation and dyspepsia are the main adverse effects. It raises triglycerides, so it is avoided when triglycerides are high, and it is contraindicated in bowel obstruction and a history of pancreatitis from hypertriglyceridaemia. It can reduce absorption of other drugs, including levothyroxine, some oral contraceptives and fat-soluble vitamins, which should be taken several hours apart.

Sourcing notes. Generic tablets are available in the US. The tablets are large and doses high, which affects adherence; an oral suspension exists for patients who cannot swallow them. Registration outside the US and Europe is limited.

Colesevelam Hydrochloride — third party manufacturing & bulk supply

Colesevelam Hydrochloride 625 mg, 3.75 g is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Colesevelam Hydrochloride is supplied as Tablets / Oral suspension — supplied in more than one dosage form, each with its own manufacturing economics, so the indicative MOQ is a minimum order value of USD 5,000 per product. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Colesevelam Hydrochloride listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Colesevelam hydrochloride is listed as Tablets / Oral suspension in 625 mg, 3.75 g. Further strengths and pack presentations are confirmed with the manufacturer at RFQ stage.

Colesevelam hydrochloride is referenced against Welchol(USA), Cholestagel (EU/UK). Reference brands are shown for identification only and remain the property of their respective trademark owners.