Chlorothiazide Suppliers & Bulk Manufacturers

Available Forms: Tablets / Oral suspension / Injection

Available Strengths: 250 mg, 500 mg, 250 mg/5 mL, 500 mg/vial

Reference Brands: Diuril (USA/EU)

Category: Heart Disorder

Chlorothiazide is a thiazide diuretic used to treat high blood pressure (hypertension), edema associated with heart failure, liver cirrhosis, or kidney disorders. It works by increasing sodium and water excretion through the kidneys, helping reduce blood pressure and swelling.

Product Description:

Chlorothiazide was the first thiazide diuretic and remains the only one available for intravenous use. It blocks the sodium-chloride cotransporter in the distal convoluted tubule, increasing excretion of sodium and water. Its blood-pressure lowering effect comes only partly from that; with continued use, peripheral resistance falls, which accounts for most of the long-term benefit.

Orally it is used for hypertension and for oedema in heart failure, kidney disease and cirrhosis. Its distinct role today is the intravenous form, given in acute decompensated heart failure to overcome resistance to loop diuretics — adding a thiazide blocks sodium reabsorption further along the tubule, an approach called sequential nephron blockade. Hypokalaemia, hyponatraemia, hypomagnesaemia, raised uric acid and raised glucose are the expected metabolic effects, and electrolytes are monitored, particularly when it is combined with a loop diuretic, where the diuresis can be dramatic.

Sourcing notes. The oral tablet and suspension are cheap generics, while the intravenous vial has a much narrower supplier base and a history of shortage and steep pricing in the US. Buyers should state which presentation they need. Hospital demand centres on the injection; metolazone is the usual oral alternative for sequential blockade.