Plerixafor 20 mg/mL Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 20 mg/mL

Reference Brands: Mozobil (USA/EU)

Category: Critical Care

Plerixafor is a Critical Care product available as Injection in strengths 20 mg/mL. It corresponds to the reference brand Mozobil (USA/EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Plerixafor, marketed under the brand name Mozobil, is a targeted immunostimulant used to mobilize hematopoietic stem cells into the bloodstream for patients undergoing stem cell transplantation. It is primarily indicated for individuals with lymphoma or multiple myeloma who are preparing for autologous stem cell transplantation. The mobilized stem cells are collected from peripheral blood and later reinfused into the patient to restore healthy bone marrow function.

Plerixafor works by selectively blocking the CXCR4 chemokine receptor on hematopoietic stem cells, disrupting their interaction with the bone marrow niche. This mechanism allows stem cells to move from the bone marrow into peripheral circulation, where they can be efficiently collected. While granulocyte colony-stimulating factor (G-CSF) is commonly used for stem cell mobilization, about 15–20% of patients do not respond adequately. The combination of plerixafor with G-CSF significantly increases the likelihood of successful mobilization, ensuring enough stem cells are available for transplantation.

Originally developed by AnorMED and later acquired by Genzyme, Mozobil has become a critical tool in modern hematology, providing an effective and reliable method to improve transplantation outcomes in patients with hematologic malignancies. Its use is carefully supervised in specialized clinical settings to maximize efficacy and safety.