Pentamidine Isethionate bulk supplier for pharma manufacturers

Pentamidine Isethionate 300 mg Suppliers & Bulk Manufacturers

Available Forms: Injection / Inhalation solution

Available Strengths: 300 mg

Reference Brands: Pentam (USA), Nebupent (USA)

Pentamidine Isethionate is a Critical Care product available as Injection / Inhalation solution in strengths 300 mg. It corresponds to the reference brands Pentam (USA), Nebupent (USA). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

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Product Description:

Pentamidine isethionate is an aromatic diamidine active against a range of protozoa and against Pneumocystis jirovecii. Its mechanism is not fully resolved but centres on binding to kinetoplast DNA and interference with nucleic acid and folate metabolism in the parasite.

It is used for Pneumocystis pneumonia in patients intolerant of co-trimoxazole, given intravenously for treatment or by nebuliser for prophylaxis, and in early-stage Trypanosoma brucei gambiense infection and some forms of leishmaniasis. The toxicity is severe enough to shape practice: hypotension during infusion, pancreatic beta-cell injury producing hypoglycaemia that may be followed by permanent diabetes, nephrotoxicity, pancreatitis and QT prolongation. The inhaled route largely avoids the systemic effects but only protects the lung.

Sourcing notes. A WHO Essential Medicine with a narrow manufacturer base, and demand that sits mostly with national programmes, donation schemes and NGOs treating human African trypanosomiasis rather than with commercial distributors. Sterile lyophilised powder manufacture. The inhalation presentation needs a compatible nebuliser to be usable, so confirm what the buyer actually has before quoting that form.

Pentamidine Isethionate — third party manufacturing & bulk supply

Pentamidine Isethionate 300 mg is available through PharmaTradz for wholesale and bulk supply as well as on a third party (contract) manufacturing basis. Buyers sourcing this product generally take one of three routes:

Wholesale / bulk supply Stock or scheduled supply from an existing manufacturer. The fastest route where the product is already registered in your market.

Third party manufacturing Manufactured to your specification and packed under your own brand and label — suits distributors and brand owners building a portfolio in their market.

Dossier licensing Where a CTD, EU-CTD or ACTD dossier exists it can often be licensed for filing in your name, compressing market entry from years to months.

Indicative minimum order quantity

Pentamidine Isethionate is supplied as Injection / Inhalation solution — supplied in more than one dosage form, each with its own manufacturing economics, so the indicative MOQ is a minimum order value of USD 5,000 per product. Actual MOQ is confirmed by the allocated manufacturer against your pack presentation and destination market. See full supply terms for dossier formats, market availability and shelf life.

Manufacturers of Pentamidine Isethionate listed on PharmaTradz hold site-level approvals across WHO-GMP, EU-GMP, USFDA, ANVISA and TGA, verified at onboarding.

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Frequently Asked Questions

Pentamidine isethionate is used for the treatment and prevention of Pneumocystis jirovecii pneumonia, and for the treatment of protozoal infections such as African trypanosomiasis and leishmaniasis, particularly in immunocompromised patients.

Pentamidine isethionate is a synthetic diamidine compound formulated as an isethionate salt to improve solubility and suitability for parenteral and inhalation administration.

Common trade names include Nebupent and Pentam 300, along with region-specific brands such as Pentacarinat.

Pentamidine isethionate is manufactured by multiple pharmaceutical companies worldwide, including branded and generic manufacturers supplying hospital and critical care markets.

The complete generic name is pentamidine isethionate.

Brand names include Nebupent, Pentam 300, and Pentacarinat.

Pentamidine isethionate is manufactured in regulated pharmaceutical facilities in regions such as the USA and Europe and supplied globally for hospital and specialty use.