Methylprednisolone Suppliers & Bulk Manufacturers

Available Forms: Injectable (IV/IM) – powder for solution

Available Strengths: 40 mg, 125 mg, 500 mg, 1 g vials

Reference Brands: Solu-Medrol (US & EU)

Category: Critical Care

Methylprednisolone sodium succinate powder for injection in 40 mg, 125 mg, 500 mg and 1 g vials, for intravenous or intramuscular use. For hospitals, critical care buyers, importers and tender buyers.

Product Description:

Methylprednisolone is an intermediate-acting glucocorticoid with strong anti-inflammatory and immunosuppressive effects and little salt-retaining activity. This page covers methylprednisolone sodium succinate, a sterile powder for solution in 40 mg, 125 mg, 500 mg and 1 g vials for intravenous or intramuscular use. The water-soluble succinate ester makes rapid intravenous dosing possible, so this is a hospital and emergency product. Some presentations are two-compartment vials with built-in diluent. Do not confuse it with methylprednisolone acetate, a depot suspension never given intravenously.

Typical uses include severe allergic reactions as an adjunct to adrenaline, acute severe asthma, flares of rheumatic and connective tissue disease, multiple sclerosis relapses and acute transplant rejection. Pulse doses of 500 mg to 1 g are infused intravenously over at least 30 minutes, because rapid injection of large doses has been linked to arrhythmias and circulatory collapse. Pharmacists check for active infection, diabetes, as glucose rises, and live vaccines. Some 40 mg formulations contain bovine lactose and carry a cow's milk allergy warning.

Sourcing notes. This prescription-only sterile injectable needs a CTD or ACTD dossier with sterility assurance and container closure data, and stability at 30 °C/75% RH for Zone IVb markets. The dry powder is stored at room temperature, protected from light, with no cold chain; reconstituted solution is used promptly. Each batch CoA should cover assay, related substances including free methylprednisolone, sterility and bacterial endotoxins. Request the sterile GMP certificate and a CoPP. Ask whether any diluent contains benzyl alcohol, which matters for neonates, and state the vial type when you enquire.