Phenoxybenzamine Hydrochloride 10 mg, 20 mg Suppliers & Bulk Manufacturers

Available Forms: Capsules

Available Strengths: 10 mg, 20 mg

Reference Brands: Dibenzyline (USA/EU)

Category: Heart Disorder

Phenoxybenzamine Hydrochloride is a Heart Disorder product available as Capsules in strengths 10 mg, 20 mg. It corresponds to the reference brand Dibenzyline (USA/EU). Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Phenoxybenzamine hydrochloride is a long-acting, non-selective alpha-adrenergic blocker used primarily in the treatment of hypertension, particularly hypertension caused by pheochromocytoma. It has a slower onset of action and a prolonged duration compared with other alpha-blocking agents, making it especially effective for sustained blood pressure control. Phenoxybenzamine is commonly administered prior to surgical intervention in patients with pheochromocytoma to prevent hypertensive crises.

The drug exerts its antihypertensive effect by forming a permanent covalent bond with alpha-adrenergic receptors, thereby preventing the binding of catecholamines such as epinephrine and norepinephrine. This irreversible blockade results in vasodilation of blood vessels, leading to a sustained reduction in vascular resistance and blood pressure. A known pharmacological effect associated with this mechanism is reflex tachycardia.

Phenoxybenzamine was the first alpha-blocker used in the treatment of benign prostatic hyperplasia, although its use for this indication has declined due to unfavorable side effects. It has also been utilized in conditions such as hypoplastic left heart syndrome and complex regional pain syndrome type 1, where its antiadrenergic properties may provide clinical benefit, particularly when initiated early in disease progression.