Enalaprilat 1.25 mg/m Suppliers & Bulk Manufacturers

Available Forms: Injection

Available Strengths: 1.25 mg/m

Reference Brands: Generic formulations marketed under different names

Category: Heart Disorder

Enalaprilat is a Heart Disorder product available as Injection in strengths 1.25 mg/m. It corresponds to the reference brand Generic formulations marketed under different names. Verified GMP manufacturers and suppliers on PharmaTradz offer it in bulk for import worldwide, with regulatory documentation and dossier support available on request.

Product Description:

Enalaprilat injection is an intravenous angiotensin-converting enzyme (ACE) inhibitor used primarily in the management of hypertension when oral therapy is not feasible, such as in hospitalized or critically ill patients. It is the active metabolite of enalapril maleate, an oral prodrug, and is poorly absorbed through the gastrointestinal tract, which necessitates intravenous administration for effective therapeutic action.

Pharmacologically, enalaprilat works by competitively inhibiting the angiotensin-converting enzyme, thereby blocking the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor; its inhibition results in vasodilation, leading to a reduction in systemic vascular resistance and blood pressure. Additionally, enalaprilat decreases angiotensin II-mediated aldosterone secretion from the adrenal cortex. This reduction in aldosterone promotes sodium excretion and increases water outflow, further contributing to blood pressure control.

Enalaprilat is indicated for patients who require rapid blood pressure management and cannot tolerate oral medications. Its clinical use requires careful dosing, monitoring of renal function, electrolytes, and blood pressure, as well as attention to contraindications, warnings, and potential drug interactions. Enalaprilat plays a significant role in acute care settings where controlled and effective antihypertensive therapy is essential.