Ofloxacin Tablets 200 mg, 400 mg Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 200 mg, 400 mg

Reference Brands: Floxin (USA)

Category: Antibiotics

Ofloxacin film-coated tablets, 200 mg and 400 mg, a fluoroquinolone antibiotic for urinary, respiratory and sexually transmitted infections. For importers, distributors, hospitals and tender buyers of oral antibiotics.

Product Description:

Ofloxacin is a fluoroquinolone antibacterial. It blocks DNA gyrase and topoisomerase IV, enzymes bacteria need to copy and separate their DNA, and so kills susceptible organisms. It covers many Gram-negative bacteria, staphylococci and atypical organisms such as chlamydia, with weaker activity against streptococci. This page covers film-coated tablets of 200 mg and 400 mg. Oral absorption is almost complete, so the tablet gives blood levels close to an infusion, and the strengths allow once- or twice-daily dosing.

Labelled uses include urinary and lower respiratory tract infections, uncomplicated gonorrhoea, non-gonococcal urethritis and cervicitis, and pelvic inflammatory disease alongside other agents; it also features in some leprosy regimens. Gonococcal resistance is now common, so local guidance governs that use. Regulators restrict systemic fluoroquinolones to cases where other antibiotics are unsuitable, because of rare, disabling effects on tendons, muscles, joints and nerves, and risks of QT prolongation and aortic aneurysm. Antacids, iron, zinc and calcium bind ofloxacin, so doses are spaced about two hours apart.

Sourcing notes. Ofloxacin tablets are prescription-only, and many markets apply antibiotic stewardship rules to their sale. Ask for a CTD or ACTD dossier with a bioequivalence study and zone IVb stability for tropical markets. Aluminium or PVC/PVdC blisters that protect from light and moisture are usual, at room temperature. Check that the leaflet carries current fluoroquinolone safety warnings for your market. Documents to ask for are a batch CoA, the site GMP certificate and a CoPP. Specify strength, blister count, quantity, leaflet language and shelf life on arrival.

Also known as: ofloxacine (French), ofloksasin (Turkish, Indonesian), офлоксацин (Russian), أوفلوكساسين (Arabic), 氧氟沙星 (Chinese), オフロキサシン (Japanese), ออฟลอกซาซิน (Thai).